I have two groups of data: In every group there are 29 subgroups, in every subgroup, there are 1-15 numbers ranged from 0 to 80. The subgroups are DEPENDENT of each other.
I wanna compare whether these two groups are sgnificantly different
without mixing all numbers in subgroups together. How should I do the analysis?

To make one example of this question, suppose:
2 groups, in every group there are only 3 subgroups, in every subgroup
there are at most 5 numbers ranged from 0 to 80:

group 1:
subgroup a: 0.1, 23, 44, 12.5, 5.0
subgroup b: 24
subgroup c: 23, 44

group 2:
subgroup a: 32, 45, 5.5, 6.7
subgroup b: 22.2, 45, 56, 52, 10
subgroup c: 2.2, 4.5, 6.1, 32

In every group, the 3 subgroups are not independent of each other. How can I compare whether group 1 and 2 are significantly different from each other, without mixing the 8 numbers in group 1 together and mixing the 13 numbers in group 2 together?